● Secretary
   Ms. Misia Wu
   email: misia@gate.sinica.edu.tw
   Phone: (02) 2787-1306

● NRPB Program PI and Coordinator
   Dr. Ying-Ta Wu
   email: ywu@gate.sinica.edu.tw
   Phone: (02) 2787-1237

● Compound collection and development
   Dr. Shi-Shan Mao
   email: sshanmao@gate.sinica.edu.tw
   Phone: (02) 2787-1303

● Assay Development
   Dr. T-J Rachel Cheng
   email: tingjenc@gate.sinica.edu.tw
   Phone: (02) 2787-1267

● HTS and Cheminformatics
   Dr. Ying-Ta Wu
   email: ywu@gate.sinica.edu.tw
   Phone: (02) 2787-1237

● Medicinal Chemistry
   Dr. Jim-Ming Fang
   email: jmfang@ntu.edu.tw
   Phnoe: (02) 2787-1266
              (02) 3366-1663


The Ultra High-Throughput Drug Screening (uHTS) Facility established in the Genomics Research Center, Academia Sinica (GRC) is the first of its kind in Asia. This facility is built to establish a versatile compounds library, create and store a chemical database, develop and conduct high-throughput screening assays, and provide drug candidate related information. The GRC uHTS has been funded by the National Research Programs for Biopharmaceuticals (NRPB) as the “ChemBank and High Throughput Screening (CB & HTS) Resource Center (SB-1) of NRPB since 2011.

The mission of the ChemBank and High Throughput Screening Resource Center (SB-1) is to provide high-throughput screening (HTS) services by using GRC’s 2-million compound library to assist investigators in identifying bioactive compounds for target mechanism study and therapeutics discovery. The Ultra High-Throughput Screening (uHTS) facility in GRC is competent to develop and automate biological assays for high throughput screening and conduct big data analysis for cheminformatics. Hence, our objective is to provide comprehensive and cost-effect HTS services, making HTS accessible and useful to all investigators.

To accelerate the finding from the curiosity driven study to medical practice has become the main subject that we are facing today. Thanks to the advance in molecular biology and informatics, investigators can now reveal more clearly than before the potential disease targets and molecular pathways which they involve. On the other hand, the use of natural occurring and synthetic small molecules for the treatment of diseases is well established in human history. Therefore, the CB&HTS Resource Center can help the investigators to rapidly identify bioactive compounds to modulate diseases and so to make usefulness of basic research for the development of new practical applications.

The GRC’s uHTS system is operated by a group of experienced staff in developing and automating biological assays as well as conducting biochemical and cell-based high-throughput screens. In addition, this Resource Center has medicinal chemists and cheminformatics talents to add values to HTS screening services. It is one important platform at the initial stage of translation research for multi-disciplinary collaboration, linking chemists and biologists to explore disease targets and identify potential interesting compounds for both mechanism studies and drug discovery.

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