● Secretary
   Ms. Misia Wu
   email: misia@gate.sinica.edu.tw
   Phone: (02) 2787-1306

● NRPB Program PI and Coordinator
   Dr. Ying-Ta Wu
   email: ywu@gate.sinica.edu.tw
   Phone: (02) 2787-1237

● Compound collection and development
   Dr. Shi-Shan Mao
   email: sshanmao@gate.sinica.edu.tw
   Phone: (02) 2787-1303

● Assay Development
   Dr. T-J Rachel Cheng
   email: tingjenc@gate.sinica.edu.tw
   Phone: (02) 2787-1267

● HTS and Cheminformatics
   Dr. Ying-Ta Wu
   email: ywu@gate.sinica.edu.tw
   Phone: (02) 2787-1237

● Medicinal Chemistry
   Dr. Jim-Ming Fang
   email: jmfang@ntu.edu.tw
   Phnoe: (02) 2787-1266
              (02) 3366-1663

 
 
 
 
The GRC uHTS Systems
 
Advanced in miniaturization and automation as well as furnished with extensive compound collections, screening 1 million molecules in a day has become feasible at the Genomics Research Center, Academia Sinica. The GRC’s uHTS systems are composed of a screening system and a hit-picking system to provide unsurpassed screening capacity.  Both systems are equipped with 6-axis robot arms for dispatching automatic process.  The screening system integrates with two dispensers for handling various dispensing modes (0.25uL~10uL), one pintool with precision pins (50nL slot) for transferring compounds, and one micro-plate CCD imager with various reading methods for reading assay results. There are three temperature and humidity controlled incubators in the screening system for culturing cell lines in 1536-well micro-titer-plates. Each incubator can accommodate 486 assay plates, holding about 700,000 individual assays.  The hit-picking system receives hit list from the screening system and operates “cherry-picking” movements for collecting hit compounds from the compound library.  The resulted hit-compound plates are good for reconfirmation assays and/or other follow-up validations.
 
 
 
 
 
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